We work with oncology biorepositories, cancer biobanks and post mortem donor centres to supply the cancer specimens you require, with particular expertise in solid tumor samples.

 

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Clinical biobank tissue samples:

Clinical biosample formats:

Our partner cancer repositories can provide cancer FFPE paraffin blocks and frozen tumor samples as well as cancer serum samples, cancer plasma samples and cancer buffy coat samples matched from the same oncology patients. These may already be available from a cancer tissue bank or collected prospectively.  (Fresh tumor samples may also be available- please email This email address is being protected from spambots. You need JavaScript enabled to view it. with details of your cancer sample needs.) 

Follow up cancer samples, such as tumor metastases samples, removed subsequent to removal of the primary tumor sample, may also be available from our clinical cancer biobank, along with blood samples (serum, plasma, buffy coat) donated on each day of surgery.

Normal control tissue samples may be available from the same or different patients (normal adjacent to tumor) or from operations for other conditions, such as obstructions or inflammatory conditions (for example, non-resectable polyp in non-cancerous bowel/intestine patients), for comparison purposes. Normal bone marrow may also be available surplus to diagnostic requirements.

 

Clinical biosample data:

Our clinical samples are highly annotated; in-depth clinical data is available from our clinical cancer biorepository partners to inform your cancer sample research. These data include demographic information, certain lifestyle details, general and disease-specific data, including treatment details and clinical histories as well as follow-up treatment data. On receipt of an order, our partner site's staff will ensure that the time-consuming processes of extracting and screening through these patient data to search for suitable tissue samples and/or blood samples are carried out so that you can receive the most suitable high quality annotated human tissue cancer samples.

Please e-mail us on This email address is being protected from spambots. You need JavaScript enabled to view it. to see an example of a typical cancer tissue sample donor pathology report from our cancer tissue bank partner site, illustrating the kind of clinical, histopathological and marker data we can make available and the range and volumes of frozen cancer tissue samples, FFPE cancer tissue samples, cancer blood samples (cancer serum samples, cancer plasma samples and cancer buffy coat samples) already banked at our clinical partners' biobank.

Biomarker data/ information regarding particular mutations or alleles is available where these form an increasingly standard part of clinical care; please inquire about availability at our clinical centers' biobanks (This email address is being protected from spambots. You need JavaScript enabled to view it.).

  

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Post mortem tissue samples or organs:

Post mortem cancer sample availability:

If you require large tissue samples / pieces or whole organs, normal biosamples that are not compatible with normal-adjacent or inflammatory conditions, or require tumor tissue samples that are too inaccessible, or too advanced for surgery, consider our post mortem prospective human tissue collection service.

Our skilled body donation partners may also have more ready access to fresh tumor specimens than our clinical sites, due to the larger size and number of cancer samples available from each donor.

Tumors specimens are available in larger quantities per patient, as biosamples do not need to be retained for diagnosis and the cancer is at an advanced stage.

Metastases will often be available from a range of metastatic sites.

Furthermore, your cancer research may benefit from receiving tumor samples in situ in the organ or tissue environment in which it developed, and access to this sort of cancer sample can usually only be achieved by studying donors who have donated their bodies for research and education.

Post mortem cancer sample formats:

Cancer samples can be provided fresh, in the buffer or medium of your choice, frozen or snap-frozen, or fixed in 10% NBF. 

Fresh whole blood samples can also be collected in the tubes of your choice.

 

Data:

Please contact us on This email address is being protected from spambots. You need JavaScript enabled to view it. to request a typical example of an anonymized post mortem donor clinical report. Histology/ Pathology reports are not currently available for post mortem donor tissues, but we are happy to ship specimens to the service provider of your choice. 

 

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Tumor types:

The following is a non-exhaustive list of some of the tumor tissue sample types available for research, from clinical and/ or post mortem donors. Availability may also depend on the format and your other requirements, as well as ongoing projects. 

The following samples may be available as frozen cancer tissue samples/ blocks, FFPE cancer samples - cancer paraffin blocks, cancer serum samples, cancer plasma samples & cancer buffy coat samples or as fresh cancer tissue samples. This is not a complete list; please inquire about your specific cancer biospecimen needs (This email address is being protected from spambots. You need JavaScript enabled to view it.).

 

Disease

  .............

Notes

Bladder cancer tissue samples

 

Papillary urothelial carcinoma, urothelial carcinoma (including transition cell, with endophytic growth pattern. with squamous or glandular differentiation, with focal squamous), adenocarcinoma mucinous, squamous metaplasia, urothelial dysplasia, Carcinoma in situ, Micropapillary carcinoma metastatic, Papillary urothelial neoplasm of low malignant potential (PUNLMP), Squamous cell carcinoma

     

Bone cancer & soft tissue cancer samples (adipose, muscle)

 

Sarcoma, Metastatic high grade pleomorphic sarcoma, Metastatic myxoid/round cell liposarcoma, myxoid liposarcoma, Myxofibrosarcoma, leiomyosarcoma, Metastatic pleomorphic undifferentiated sarcoma involving pulmonary parenchyma, Metastatic synovial sarcoma, Recurrent dedifferentiated liposarcoma, Schwannoma, Chondrosarcoma

     

Brain & CNS cancer tissue samples

 

Malignant glioma, Glioblastoma multiforme (GBM), Glioblastoma, Fibrillary astrocytoma samples, Fibrillary astrocytoma with gemistocytic features, Pilocytic astrocytoma, Oligodendroglioma, Anaplastic astrocytoma, meningioma (psammomatous, fibrous, angiomatous, transitional and secretory types), Angiomatous meningioma, Atypical glial proliferation with Rosenthal fibers, B-cell lymphoma in brain, Hemangioma, fibrous tumor (hemangiopericytoma), Chordoid meningioma, Craniopharyngioma adamantinomatous, Desmoplastic/nodular medulloblastoma, Ependymoma, Ganglioglioma, Gliosarcoma, Gliosis, Hemangioblastoma, small cell glioblastoma, gliomatosis cerebri, Low grade neuroglial lesion, Myxoid glioma, Pineocytoma, Pituitary adenoma, microcystic glioma, Subependymal giant cell astrocytoma, Subependymoma, Myxopapillary ependymoma, Spinal cord tumor, Paraganglioma

     

Breast cancer tissue samples 

 

Invasive & non-invasive ductal (Ductal Carcinoma In Situ, DCIS) and lobular, BRCA1/2 positive/negative, Benign breast therapy related changes, benign breast, Adenocarcinoma, phyllodes tumor, duct ectasia, apocrine metaplasia, Cribriform carcinoma, Ductal Adenocarcinoma with Apocrine, squamous differentiation), Focal atypical lobular hyperplasia,  Lobular carcinoma signet ring cell type, Papillary carcinoma,  ADH, ALH, Spindle cell carcinoma

     

Gut / Colon cancer tissue samples / Rectal cancer samples / ColoRectal Cancer (CRC) samples, Gastrointestinal tumor tissues, instestinal cancer tissue samples,  Appendix, 

 

Adenocarcinoma (/ with mucinous features), Carcinoid, Malignant mesothelioma epithielioid type, Signet ring cell carcinoma, Tubular adenoma, Tubulovillous adenoma with focal high grade dsyplasia, Metastatic mucinous colorectal adenocarcinoma, Colonic sessile serrated and hyperplastic polyps, Ulcerative Colitis with pseudopolyps, Adipose tissue with nodules of fat necrosis with embedded suture type material- negative for carcinoma, B cell lymphoma, Appendix, Ileocecal submucosal lipoma, Hyperplastic polyps, Leiomyoma, Low grade appendiceal mucinous neoplasm, Malignant mesothelioma -epithielioid type, Malignant mixed (epithelioid and spindle cell) gastrointestinal stromal tumor (GIST), Mantle cell lymphoma forming colonic massesand involving lymph nodes, Metastatic squamous cell carcinoma, Mixed adenoneuroendocrine carcinoma, mixed goblet cell carcinoid-adenocarcinoma, Papilliary serous carcinoma, Pleomorphic undifferentiated sarcorma with prominent inflammation, submucosal lipoma

     

Endometrial cancer/ womb cancer tissue samples & benign conditions; Fallopian tubes, cervical cancer

 

Adenocarcarinoma (endometrial, mullerian, endometrioid, chondroid, squamous, mucinous, serous, clear cell, signet ring, villoglandular), Adenomyosis, Endometriosis, leiomyomata,  vascular leiomyoma, Atypical endometrial hyperplasia, Benign ecto/endocervix with nabothian cysts, Benign endometrial polyps, Benign hemorrhagic cyst, Benign serous cystadenoma, benign leiomyoma, Carcinosacoma, Cear cell carcinoma, large cell neuroendocrine carcinoma, Complex atypical hyperplasia, Embryonal rhabdomyosarcoma, Endocervical adenocarcinoma in-situ, clear cell carcinoma of endocervix, Endometrioma, Lipoma, Intravascular leiomyomatosis, lobular carcinoma, Polypoid adenomyoma, Small cell neuroendocrine carcinoma, Squamous metaplasia, mesonephric carcinoma (rare), Available from clinical and post mortem donors, except for Cervical cancer: post mortem only (fresh, frozen or NBF).

     

Gastric - Stomach - Esophagus cancer tissue samples

 

Adenocarcinoma - intestinal type/ Lauren classification / Diffuse type/ Signet ring cell type, Gastric schwannoma, gastrointestinal stromal tumor (GIST),GIST spindle cell, Neuroendocrine, Esophageal cancer, 

     

Hepatic (liver) cancer tissuesamples, Bile duct cancer samples, Gall bladder cancer samples, spleen (rare)

 

Hepatic Adenoma,Adenocarcinoma - , Adenosquamous carcinoma,  Incidental bile duct adenoma, Gall bladder cancer, Focal nodular hyperplasia, Hepatocellular carcinoma (HCC) - clear cell and pleomorphic types, Inflammatory pseudotumor, Intrahepatic cholangiocarcinoma, ampullary carcinoma/ Carcinoma of the Ampulla of Vater, Spleen - B-cell lymphoma, consistent with follicular lymphoma.

     

Head and neck cancer samples

 

Usually post mortem only Mostly post mortem (fresh, frozen or NBF) 

     

Kidney cancer & Adrenal cancer tissue samples

 

Adrenal cortical adenoma, Adrenal cortical carcinoma, Angiomyolipoma, Benign renal cortical cyst, Chromophobe renal cell carcinoma, Clear cell renal carcinoma - with sarcomatoid features/ cystic change/ multilocular features, carcinoma, Clear cell papillary renal cell carcinoma, Cystic clear cell carcinoma, Epithelioid angiomyolipoma, Oncocytoma, Papillary adenoma, Papillary carcinoma, Pheochromocytoma, Renal adenomatosis, Renal cell carcinoma - with eosinophilic features, Renal epithelial neoplasm, Chronic ureteritis with nodular lymphoid hyperplasia and papillary urothelial hyperplasia,  

     

Lung cancer tissue samples (including some connective tissue cancers)

 

Adenocarcinoma (acinar, solid, lepidic, with mucinous features, micropapillary patterns, with focal signet ring cell features), Adenosquamous carcinoma, Atypical carcinoid tumor with spindle cell features, Carcinoid, Solitary Fibrous tumor, Large cell neuroendocrine carcinoma, Multiple carcinoid tumorlets, Pulmonary hamartoma (chondromatous), Reactive follicular hyperplasia and anthracosis with associated histiocytic reaction - negative for malignancy, Sarcomatoid spindle cell squamous cell carcinoma, Non-Small Cell Lung Carcinoma (NSCLC), Small cell lung carcinoma (SCLC), Squamous cell carcinoma, Neuroendocrine tumor

     

Lymphomas, Leukemias

 

Human hematologic malignancies, such as lymphomas, leukemias and myeloma, including CLL, AML, Hodgkin's Lymphoma, Hairy cell leukemia, MDS, Acute Moncytic Lymphoma, B-cell lymphoma, T-cell lymphoma, Burkitt Lymphoma, DLBCL, Non Hodgkin Lymphoma, and Multiple Myeloma are available as fresh peripheral blood, fresh bone marrow, or as frozen or FFPE bone marrow aspirate or core specimens (trephine biopsies) from the hospitals and pathology service providers we work with. Lymph node samples, as well as lymphoma tumors from other organs, may also be available.

Plasma, serum, buffy coat or whole blood may also be available  from our clinical biobank sites.

Deceased donor bone marrow  and lymph node specimens, offering large quantities of material, can also be collected prospectively. Preliminary feedback from fresh bone marrow specimens we have provided indicates high levels of viability- please inquire. Material can also be provided frozen, snap-frozen or fixed in 10% NBF.

     

Metastases

 

Many tumor types, many sites; clinical and post mortem donors.
     

Ovarian cancer tissue samples & Fallopian tube cancer tissue samples

 

Adenocarcinoma (endometrioid, mucinous, serous, clear cell), benign Brenner's tumor (very rare), Benign rete cyst with mural hilar cell proliferation, Benign endometrila polyps in a background of cystic atrophy, Benign ovarian serous cystadenofibroma, Benign hemorrhagic cyst, Benign serous cyst, Benign serous cystadenofibroma with dystrophic calcifications, Carcinosarcoma, Cellular Fibroma, Endosalpingiosis,  Endometrioma, Sex cord stromal tumor, Granulosa/Granulosa-theca cell tumor, Leiomyoma, Mixed germ cell tumor, Neuroendocrine, Papillary serous carcinoma with psammomatous calcifications, Small cell carcinoma - hypercalcemic type, Teratoma

     

Pancreatic cancer samples

 

Acinar cell carcinoma, Adenocarcinoma (ductal, mucinous, squamous differentiation), Adenocarcinoma arising in association with Intraductal papillary mucinous neoplasm of pancreas (IPMN), Hyperplastic ampullary epithelium with acute inflammation and reactive cellular changes, Incidental low grade pancreatic intraepithelial neoplasia, Mucinous cystic neoplasm, with low and focal intermediate dysplasia, Neuroendocrine carcinoma, Insulinoma, Retroperitoneal cyst of Mullerian type with focal adenocarcinoma, Serous cysta adenoma, microcystic type, Solid pseudopapillary neoplasm, Undifferentiated carcinoma with osteoclast-like giant cells, 

     

Peritoneal cancer samples (rare)

 

Adenocarcinoma, Serous adenocarcinoma, Ganglioneuroma, appendiceal mucinous neoplasm, Mesothelioma, Neurofibroma, Sebaceous carcinoma, Liposarcoma, Papillary mesothelioma

     

Prostate cancer samples

 

Post mortem (fresh, frozen or NBF) or clinical: FFPE or frozen, including castration-resistant.

     

Skin cancer samples, Melanoma samples

 

Clinical: mostly metastatic sites: FFPE & frozen, with biomarker data. Post mortem: available fresh, frozen or in 10% NBF, primary & metastases.

     

Testicular cancer samples

 

Adenomatoid tumor, Classic / seminoma, Malignant germ cell tumor, Malignant mixed germ cell tumor, Teratoma, Yolk sac tumor, Choriocarcinoma, Embyonal carcinoma, Intratubular germ cell neoplasia, Sertoli cell tumor (NOS)

     

Thyroid cancer tissue samples

 

Mostly post mortem (fresh, frozen or NBF) 

 

 

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Locations:

We work with high quality biorepositories and body donation sites located in the US to provide the cancer research samples you require.

 

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